Sinha Lab focuses on a variety of projects, all of which relate directly or indirectly to leaf development.
Genetic and molecular analysis of compound leaf development in tomato
The regulation of leaf complexity in Solanaceae
Evolution of leaf complexity
Evolution and expression of homeobox genes
Developmental Significance of RNA movement in plants
The role of Knox genes in moss development
1. Chitwood DH, Naylor DT, Thammapichai P, Weeger ACS, Headland LR, Sinha NR (2012) Conflict between intrinsic leaf asymmetry and phyllotaxis in the resupinate leaves of Alstroemeria psittacina. Frontiers in Plant Sciences. 3: 182. PMID: 22908025 [PubMed - in process]
2. Chitwood DH, Headland LR, Filiault DL, Kumar R, Jimenez-Gomez JM, Schrager AV, Park DS, Peng J, Sinha NR, Maloof JN (2012a) Native environment modulates leaf size and response to simulated foliar shade across wild tomato species. PLoS ONE. 7:e29570. PMID: 22253737 [PubMed - indexed for MEDLINE]
3. Alakonya A, Kumar R, Koenig D, Kimura S, Townsley B, Runo S, Garces HM, Kang J, Yanez A, David-Schwartz R, Machuka J and Sinha NR. Interspecific RNA Interference of SHOOT MERISTEMLESS-Like Disrupts Cuscuta pentagonaPlant Parasitism. Plant Cell [Published online before print] July 2012, doi: http:/ / dx. doi. org/ 10. 1105/ tpc. 112. 099994. PMID: 22822208 [PubMed - as supplied by publisher]
4. Townsley B, Sinha N (2012). A New Development: Evolving Concepts in Leaf Ontogeny. Annual Review of Plant Biology. 63: 535-562. PMID: 22404465 [PubMed - in process]
5. Kumar R, Ichihashi Y, Kimura S, Chitwood DH, Headland LR, Peng J, Maloof JN and Sinha NR (2012). A high-throughput method for Illumina RNA-Seq library preparation. Front. Plant Sci. 3:202. doi: 10.3389/fpls.2012.00202
6. Chitwood DH, Headland LR, Ranjan A, Martinez CC, Braybrook SA, Koenig DP, Kuhlemeier C, Smith RS, Sinha NR (2012c). Leaf asymmetry as a developmental constraint imposed by auxin-dependent phyllotactic patterning. Plant Cell. 24: 1-10. PMID: 22722959 [PubMed - in process]
7. Chitwood DH, Headland LR, Kumar R, Peng J, Maloof JN, Sinha NR (2012b). The developmental trajectory of leaflet morphology in wild tomato species. Plant Physiol. 158: 1230-1240 [Featured cover article, March issue]. PMCID: PMC3291254
8. Ji J, Strable J, Shimizu R, Koenig D, Sinha N, Scanlon MJ. WOX4 promotes procambial development. Plant Physiol. 2009 Dec 31. [Epub ahead of print]PMID: 20044450 [PubMed - as supplied by publisher]
9. David-Schwartz R, Koenig D, Sinha NR. LYRATE is a key regulator of leaflet initiation and lamina outgrowth in tomato. Plant Cell. 2009 Oct;21(10):3093-104. Epub 2009 Oct 9.PMID: 19820188 [PubMed - in process]
10. Uchida N, Kimura S, Koenig D, Sinha N. (2009). Coordination of leaf
development via regulation of KNOX1 genes. J Plant Res. 2009 Jun 9. [Epub ahead
of print] PMID: 19506991
11. Koenig D, Bayer E, Kang J, Kuhlemeier C, Sinha N. (2009). Auxin patterns Solanum lycopersicum leaf morphogenesis. Development. 136(17):2997-3006.
12. David-Schwartz R, Runo S, Townsley B, Machuka J, Sinha N. (2008). Long-distance transport of mRNA via parenchyma cells and phloem across the host-parasite junction in Cuscuta. New Phytol. 179(4):1133-41.
13. Kimura, S., Koenig, D., Kang, J., Yoong F-Y., and Sinha N. (2008) Natural Variation in Leaf Morphology Results from Mutation of a Novel KNOX Gene. Curr. Biol. 18: 672-677 (featured on cover)
14. Champagne, C., Goliber, TE., Wojciechowski, M., Mei, RW., Townsley, B., Wang, K., Paz, M., Geeta, R. amd Sinha, Neelima. (2007). Compound leaf development and evolution in the legumes. Plant Cell 19:3369-3378.
15. Uchida, N., Townsley, B., Chung, K-H., and Sinha, N. (2007) Regulation of SHOOT MERISTEMLESS genes via an upstream-conserved noncoding sequence coordinates leaf development. PNAS 104:15953-15958.
16. GarcÍs, HMP., Champagne, CEM., Townsley, BT., Park, S., Malho, R., Pedroso, MC., Harada, JJ., and Sinha, Neelima. (2007) Evolution of asexual reproduction in leaves of the genus KalanchoŽ. PNAS 104:15578-15583.
17. Sharon Kessler, Brad Townsley, and Neelima Sinha. (2006) L1 Division and Differentiation Patterns Influence Shoot Apical Meristem Maintenance. Plant Physiol. 141: 1349-1362.
18. Groot, E., Sinha, N. and Gleissberg, S. (2005) Expression patterns of STM-like KNOX and Histone H4 genes in shoot development of the dissected-leaved basal eudicot plants Chelidonium majus and Eschscholzia californica (Papaveraceae). Plant Molecular Biology 58:317Ė331
19. Champagne C., Sinha N. (2004) Compound leaves: equal to the sum of their parts? Development 131:4401-4412
20. Kessler, S. and Sinha, N. (2004) Shaping up: The genetic control of leaf shape. Current Opinion in Plant Biology 7: 65-72
21. Kim, M., McCormick, S., Timmermans, M., and Sinha, N. (2003). The expression domain of PHANTASTICA determines leaflet placement in compound leaves. Nature 424: 438-443
22. Pham, T. and Sinha, N. (2003) Role of KNOX genes in shoot and leaf development of Welwitschia mirabilis. International Journal of Plant Science 164:333-343
23. Kim, M., Pham, T., Hamidi, A., McCormick, S., Kuzoff, R., and Sinha, N. (2003) Reduced leaf complexity in tomato wiry mutants suggests a role for PHAN and KNOX genes in generating compound leaves. Development 130: 4405-4415 (featured on the cover)
24. Kim, M. and Sinha, N. (2003) Regulating Shapes and Sizes. Developmental Cell 4: 441-442
25. Bharathan, G., Goliber, T. E., Moore, C., Kessler, S., Pham, T., and Sinha, N. (2002) Homologies in leaf form inferred from KNOXI gene expression during development. Science 296: 1858-1860
26. Kessler, S., Seiki, S., and Sinha, N. (2002) Xcl1 causes delayed oblique periclinal cell divisions in developing maize leaves, leading to cellular differentiation by lineage instead of position. Development 129:1859-1869
27. Bharathan, G. and Sinha ,N. (2001) The regulation of compound leaf development. Plant Physiology 127:1533-1538
28. Kim, M., Canio, W. C., Kessler, S. A., and Sinha, N. (2001) Developmental Changes Due to Long-Distance Movement of a Homeobox Fusion Transcript in Tomato. Science 293:287-289
29. Kessler, S., Kim, M., Pham, T., Weber, N., and Sinha, N. (2001) Mutations altering leaf morphology in tomato. International Journal of Plant Science 162(3):475-492.
30. Sinha, N. (2000) The response of Epidermal cells to contact. Trends in Plant Science 5:233-34.
31. Sinha, N. (1999) Leaf Development in the Angiosperms. Annual Reviews of Plant Physiology and Plant Molecular Biology 50:419-46.
32. Bharathan, G., Janssen, B-J., Kellogg, E. A., and Sinha, N. (1999) Phylogenetic relationships and evolution of the KNOTTED class of plant homeodomain proteins. Molecular Biology and Evolution 16:553-563
33. Goliber, T. E., Kessler, S. A., Chen, J-J., Bharathan, G., and Sinha, N. (1998) Genetic, Molecular, and Morphological Analysis of Compound leaf development. Current Topics in Developmental Biology 41: 259-290.
34. Janssen, B-J., Lund, L., and Sinha, N. (1998) Overexpression of a homeobox gene, LeT6, reveals indeterminate features in the tomato compound leaf. Plant Physiology. 117 (3):771-786.
35. Janssen, B-J., Williams, A., Chen, J-J., Mathern, J., Hake, S., and Sinha, N. (1998) Isolation and characterization of two knotted-like homeobox genes from tomato. Plant Molecular Biology 36:417-425
36. Bharathan, G., Janssen, B-J., Kellogg, E. A., and Sinha, N. (1997) Did homeodomain proteins duplicate before the origin of angiosperms, fungi, and metazoa? Proceedings of the National Academy of Sciences 94: 13749-13753.
37. Chen, J-J., Janssen, B-J., Williams, A., and Sinha, N. (1997) A gene fusion at a homeobox locus: alterations in leaf shape and implications for morphological evolution. Plant Cell. Vol 9: 1289-1304.
38. Sinha, N. (1997) Simple and compound leaves: division or multiplication? Trends in Plant Science. 2: 396-402.
39. Sinha, N. and Kellogg, E. A. (1996) Parallelism and Diversity in Multiple Origins of C4 Photosynthesis in the Grasses. American Journal of Botany 83:1458-1470.
40. Sinha, N. and S. Hake. (1994) The Knotted leaf blade is a mosaic of blade, sheath, and auricle identities. Developmental Genetics 15:401-414.
41. Sinha, N., R. Williams and S. Hake. (1993) Overexpression of the homeobox gene, Knotted-1, causes a switch from determinate to indeterminate cell fates. Genes and Development 7:787-795.
42. Freeling, M., R. Bertrand-Garcia and N. Sinha. (1992) Maize mutants and variants altering developmental time and their heterochronic interactions. BioEssays 14:227-236.
43. Vollbrecht, E., B. Veit, N. Sinha, and S. Hake. (1991) The developmental gene Knotted-1 is a member of a maize homeobox gene family. Nature 350(6315):241-243.
44. Sinha, N. and S. Hake. (1990) Mutant characters of Knotted maize leaves are determined in the innermost tissue layers. Developmental Biology 141:203-210.